Journal
TRENDS IN IMMUNOLOGY
Volume 28, Issue 11, Pages 491-496Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.05.008
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- Intramural NIH HHS Funding Source: Medline
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CD1d-restricted natural killer T (NKT) cells have at least two subsets: type I, semi-invariant TCR alpha chain-expressing (V alpha 14J alpha 18 in mice, V alpha 24J alpha 18 in humans), and type II, variable TCR alpha chain-expressing. The protective role of NKT cells in tumor immunosurveillance and immunity has been well documented but paradoxically, there are also studies ascribing a suppressive role to these cells. Recent studies have resolved this paradox by revealing distinct roles for the two types of NKT cells, whereby type I NKT cells enhance anti-tumor responses and type II NKT cells suppress these responses. The finding of cross-regulation between the two types of NKT cells suggests a new immunoregulatory axis. Consideration of the cross-talk of NKT cells along with the well-defined suppression by regulatory T cells could provide new insights into cancer immunotherapy.
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