Journal
MICROBES AND INFECTION
Volume 9, Issue 14-15, Pages 1644-1651Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2007.09.004
Keywords
interferon; GTPase; innate immunity
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NIAID NIH HHS [AI57831, R01 AI057831] Funding Source: Medline
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IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hernatopoiesis following infection. Published by Elsevier Masson SAS.
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