Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 66, Issue -, Pages 77-80Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2007.078998
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Funding
- NIAID NIH HHS [R01 AI061772, AI61772] Funding Source: Medline
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Innate responses to microbes are mediated in large part by toll-like receptors (TLRs), which recognise a diverse range of molecules produced by viruses, bacteria and fungi. Great effort has been directed towards translating this knowledge into the development of new therapies for a wide spectrum of diseases, including infectious, malignant, autoimmune and allergic diseases. This review will provide a brief update on completed, ongoing and planned clinical trials of TLR ligand-based therapies for the treatment of diseases in humans.
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