Journal
CLINICAL LYMPHOMA & MYELOMA
Volume 7, Issue 9, Pages 587-589Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2007.n.045
Keywords
bone turnover; N-telopeptide; nuclear factor-kB; osteoblasts; proteasomes
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Background: The antimyeloma agent bortezomib functions as an inhibitor of nuclear factor (NF)-kB. Although NF-kB inhibition is predicted to affect osteoclast function, preclinical and clinical studies have primarily reported an effect on osteoblasts. Patients and Methods: We examined parameters of bone turnover prospectively in patients with multiple myeloma treated with bortezomib before and after autologous transplantation. Thirty-nine patients received 2 cycles of bortezomib on days 1, 4, 8, and 11 of a 21-day cycle. After high-dose melphalan with autologous stem cell transplantation, bortezomib 1.3 Mg/M-2 on days 1, 8, 15, and 22 of a 5-week cycle was administered as maintenance therapy. Results: During posttransplantation bortezomib, decreases in the urinary excretion of collagen N-telopeptide indicated that bortezomib suppresses osteoclast function. Conclusion: The effects on osteoclasts occurred in the absence of bisphosphonate treatment and independently of changes in monoclonal protein levels. Further studies exploring the role of bortezomib as a bone protective agent could be warranted.
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