Journal
NATURE REVIEWS IMMUNOLOGY
Volume 7, Issue 11, Pages 889-896Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2193
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Funding
- NIDDK NIH HHS [DK068292] Funding Source: Medline
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The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipidbased reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein - lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.
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