Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 88, Issue 1, Pages 89-93Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2007.07.008
Keywords
acquisition; autoshaping; behavior; dietary fat
Funding
- NIDA NIH HHS [R01 DA013188, DA017230, R21 DA017230-02, DA13188, R21 DA017230] Funding Source: Medline
- NIMH NIH HHS [MH65728, T32 MH065728] Funding Source: Medline
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Variations in dietary constituents such as carbohydrate are known to alter psychostimulant function in brain. Relatively few studies have examined the reinforcing effects of psychostimulants in subjects maintained on high-fat diets. The present experiment compared the rate of acquisition of an operant response for intravenous (i.v.) cocaine infusions (0.2 mg/kg) in rats fed either a chow-pellet diet or a 35.9% (by weight) high-fat diet for 45 days prior to cocaine self-administration testing. Rats maintained on a high-fat diet for 45 days exhibited diminished acquisition of cocaine self-administration, and this effect was not a function of dietary-induced obesity. The results suggest that prolonged exposure to a high-fat diet diminishes the efficacy of cocaine reinforcement. (C) 2007 Elsevier Inc. All rights reserved.
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