Journal
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Volume 37, Issue 5, Pages 577-582Publisher
WILEY
DOI: 10.1111/ijlh.12413
Keywords
High-performance liquid; chromatography; capillary; electrophoresis; hemoglobin A(2); beta-thalassemia
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Automated high performance liquid chromatography and Capillary electrophoresis are used to quantitate the proportion of Hemoglobin A(2) (HbA(2)) in blood samples order to enable screening and diagnosis of carriers of beta-thalassemia. Since there is only a very small difference in HbA(2) levels between people who are carriers and people who are not carriers such analyses need to be both precise and accurate. This paper examines the different parameters of such equipment and discusses how they should be assessed. Int.
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