Journal
ARCHIV DER PHARMAZIE
Volume 340, Issue 11, Pages 591-598Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200700121
Keywords
antitumor; benzazoles; microwave; pyrazolone; quinoline
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New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds la, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.
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