Journal
JOURNAL OF GENERAL VIROLOGY
Volume 88, Issue -, Pages 3007-3012Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.83042-0
Keywords
-
Categories
Ask authors/readers for more resources
Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (> 2.5-fold, P < 0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1 beta Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available