Journal
AMERICAN HEART JOURNAL
Volume 154, Issue 5, Pages 899-907Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ahj.2007.06.026
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Background Sudden cardiac death (SCD) is a devastating complication of hypertrophic cardiomyopathy (HCM). The optimal strategy for the primary prevention of SCID in HCM remains controversial. Methods Using a Markov model, we compared the health benefits and cost-effectiveness of 3 strategies for the primary prevention of SCD: implantable cardioverter/clefibrillator (ICD) insertion, amiodarone therapy, or no therapy. We modeled hypothetical cohorts of 45-year-old patients with HCM with no history of cardiac arrest but at significant risk of SCID (3%/y). Results Over a lifetime, compared with no therapy, ICD therapy increased quality-adjusted survival by 4.7 quality-adjusted life years (QALYs) at an additional cost of $142800 ($30000 per QALY), whereas amiodarone increased quality-adjusted survival by 2.8 QALYs at an additional cost of $104900 ($37300 per QALY). Compared with no therapy, ICD therapy would cost <$50000 per QALY for patients (i) aged 25, with ! I risk factors for SCID, and (ii) aged 45 or 65, with >= 2 risk factors for SCD. Conclusions An ICD strategy is projected to yield the greatest increase in quality-adjusted life expectancy of the 3 treatment strategies evaluated. Combined consideration of age and the number of risk factors for SCID may allow more precise tailoring of ICD therapy to its expected benefits.
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