Journal
CLINICAL IMMUNOLOGY
Volume 125, Issue 2, Pages 165-172Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2007.06.011
Keywords
apoptosis; juvenile dermatomyositis (JDM); disease duration; skeletal muscle
Categories
Funding
- NIAMS NIH HHS [R01 AR48289, R01 AR048289-03, R01 AR048289-02, R01 AR048289] Funding Source: Medline
Ask authors/readers for more resources
Juvenile dermatomyositis (JDM) is the most common myopathy in children with characteristic skin rash and muscle weakness, in which longer duration of untreated disease was associated with less muscle weakness. The duration of untreated inflammation may alter the apoptotic pathways involved in skeletal muscle damage. Diagnostic muscle biopsies from 14 untreated patients were stained for apoptosis markers. TUNEL-positive nuclei and caspase 3 were detected within the laminin Layer, indicating apoptosis of skeletal muscle nuclei. Untreated JDM disease duration greater than 2 months (long), was associated with higher Fas-positive cell counts in the perivascular region compared with the short disease duration group, 2 months or Less. Within the long duration group, higher Fas-positive cell counts were positively associated with increased TUNEL-positive nuclei and caspase 3. We conclude that the duration of untreated disease (chronic inflammation) influences the mode of continuing cell damage and death in children with JDM. (C) 2007 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available