Journal
TETRAHEDRON
Volume 63, Issue 45, Pages 11086-11092Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.08.033
Keywords
thio-Michael; aminocatalysis; amino acid; green synthesis
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Using amino acid as a catalyst, an inexpensive, nontoxic, environmentally friendly, metal-free reaction procedure for C-S bond formation via thio-Michael addition reaction has been developed. The thio-Michael addition products were obtained in excellent yields under mild and neutral conditions. This metal-free catalytic protocol was found to be a good alternative to the existing metal catalyst methodology for the thio-Michael addition reaction. (c) 2007 Elsevier Ltd. All rights reserved.
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