Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 45, Pages 17819-17824Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0707945104
Keywords
1-octanol; patch clamp; VSDI; electroencephalogram; calcium channel
Categories
Funding
- NINDS NIH HHS [NS13742, P01 NS013742] Funding Source: Medline
Ask authors/readers for more resources
Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (Ca(v)2.1), in which N-type calcium channels (Ca(v)2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no gamma-band subthreshold oscillation, and voltage-sensitive dye imaging demonstrated an absence of cortical gamma-band-dependent columnar activation involving cortical inhibitory interneuron activity. In vivo electroencephalogram recordings showed persistent absence status and a dramatic reduction of gamma-band activity. Pharmacological block of T-type calcium channels (Ca(v)3), although not noticeably affecting normal control animals, left the knockout mice in a coma-like state. Hence, although N-type calcium channels can rescue P/Q-dependent synaptic transmission, P/Q calcium channels are essential in the generation of gamma-band activity and resultant cognitive function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available