Journal
VACCINE
Volume 25, Issue 45, Pages 7720-7731Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.08.063
Keywords
clinical trials; inactivated influenza vaccine; influenza; influenza vaccine; review; vaccine effectiveness; vaccine-preventable incidence
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Trivalent inactivated split influenza virus vaccine has been used for more than 35 years, and is currently licensed in over 100 countries. To determine vaccine-preventable influenza burden in different populations and geographic regions, we reviewed studies of vaccine effectiveness against non-specific outcomes such as upper respiratory infection, hospitalization, and death in addition to confirmed microbiologically confirmed influenza. The vaccine-preventable disease incidence was high in most studies, regardless of the outcome or population evaluated. This indicates that routine influenza vaccination can improve overall population health under a broad range of circumstances. (c) 2007 Elsevier Ltd. All rights reserved.
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