Journal
ORGANIC LETTERS
Volume 9, Issue 23, Pages 4853-4855Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol702190y
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A strategy involving the use of a self-immolative linker has been investigated for the chemiluminescent sensing of proteases. The reactive linker enabled the release of a 1,2-dioxetane light precursor. As a proof of principle, caspase-3, a key peptidase involved in apoptosis has been targeted. An in vitro assay has been carried out and proved the decomposition of the linker and the selectivity for caspase-3.
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