Journal
NATURE
Volume 450, Issue 7167, Pages 198-202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature06324
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Funding
- NIGMS NIH HHS [R01 GM025232, R01 GM025232-31] Funding Source: Medline
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Since the early 1960s, imaging studies of Drosophila sp. polytene chromosomes have provided unique views of gene transcription in vivo. The dramatic changes in chromatin structure that accompany gene activation can be visualized as chromosome puffs. Now, live-cell imaging techniques coupled with protein-DNA crosslinking assays on a genome-wide scale allow more detailed mechanistic questions to be addressed and are prompting the re-evaluation of models of transcription regulation in both Drosophila and mammals.
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