Journal
SCIENCE
Volume 318, Issue 5852, Pages 980-985Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1147851
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Funding
- NIDDK NIH HHS [T32DK07521-16, T32 DK007521] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008444] Funding Source: Medline
- NINDS NIH HHS [R21 NS053875, K08 NS044276-01, K08 NS044276, R21NS05875-1, R01 NS032764, 5K08 NS044276, R21 NS053875-01A1, R01-NS32764] Funding Source: Medline
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The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.
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