Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1171, Issue 1-2, Pages 90-97Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2007.09.034
Keywords
principal component analysis; inverse gas chromatography; hansen solubility parameters; chemometrics
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The solubility parameter (delta(2)), corrected solubility parameter (delta(T)) and its components (delta(d), delta(p), delta(h)) were determined for series of pharmaceutical excipients by using inverse gas chromatography (IGC). Principal component analysis (PCA) was applied for the selection of the solubility parameters which assure the complete characterization of examined materials. Application of PCA suggests that complete description of examined materials is achieved with four solubility parameters, i.e. delta(2) and Hansen solubility parameters (delta(d), delta(p), delta(h)) Selection of the excipients through PCA of their solubility parameters data can be used for prediction of their behavior in a multi-component system, e.g. for selection of the best materials to form stable pharmaceutical liquid mixtures or stable coating formulation. (c) 2007 Elsevier B.V. All rights reserved.
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