Journal
TETRAHEDRON LETTERS
Volume 48, Issue 46, Pages 8230-8233Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.09.074
Keywords
saponification of esters; mechanism; non-aqueous conditions; methanolysis; selective enrichment of COOH; carboxylic acids; alcohols
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A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed. (C) 2007 Elsevier Ltd. All rights reserved.
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