Journal
ANALYTICA CHIMICA ACTA
Volume 603, Issue 2, Pages 140-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2007.09.006
Keywords
carbidopa; levodopa; methyldopa; simultaneous determination; orthogonal design; chemometric
Categories
Ask authors/readers for more resources
The kinetic methodology based on the difference of reaction rates, is based on the reaction between a common oxidizing agents such as tris(1,10-phenanthroline) and iron(III) complex (ferriin, [Fe (phen)(3)](3+)) in the presence of citrate and spectrophotometrically, monitoring the changes of absorbance at the maximum wavelength of 511nm. Experimental conditions such as pH, reagents and citrate concentrations were optimized, and the data obtained from the experiments were processed by several chemometric approaches, such as artificial neural network (ANN) and partial least squares (PLS). A set of synthetic mixtures of carbidopa (CD), levodopa (LD) and methyldopa (MD) was evaluated and the results obtained by the applications of these chernometric approaches were discussed and compared. It was found that the back propagation artificial neural network (BP-ANN) method afforded better precision relatively than those of radial basis function artificial neural networks (RBF-ANN) and PLS. The proposed method was also applied satisfactorily to the determination of carbidopa, levodopa and methyldopa in real samples. (c) 2007 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available