Journal
FEBS LETTERS
Volume 581, Issue 27, Pages 5173-5177Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.10.003
Keywords
G-protein coupled receptor; GIRK channel; receptor endocytosis; postsynaptic density
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Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95 kDa (PSD-95) and PSD-93. The existence of the SSTR4/PSD-95 complex was verified by coimmunoprecipitation from transfected cells and solubilized brain membranes. In neurons, dendritically localized SSTR4 partially colocalizes with postsynaptic PSD-95. As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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