Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 13, Issue 42, Pages 5594-5597Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v13.i42.5594
Keywords
genetic; susceptibility; inflammatory bowel disease; ulcerative colitis; Crohn's disease
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Crohn's disease (CD) and ulcerative colitis (UC) are complex polygenic disorders, characterized by several genes together with environmental factors contributing to the development of inflammatory bowel disease (IBD). Recent advances in research on genetic susceptibility have allowed the identification of diverse genes at different levels: (1) Innate immunity; (2) Antigen presentation molecules; (3) Epithelial integrity; (4) Drug transporter; (5) Cell adhesion. The application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications: prediction of disease phenotype, molecular classification, prevention of complications, and prognosis. (c) 2007 WJG. All rights reserved.
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