Determination of lamotrigine by adsorptive stripping voltammetry using silver nanoparticle-modified carbon screen-printed electrodes

Carbon screen-printed electrodes (CSPE) modified with silver nanoparticles present an interesting alternative in the determination of lamotrigine (LTG) using differential pulse adsorptive stripping voltammetry. Metallic silver nanoparticle deposits have been obtained by electrochemical deposition. Scanning electron microscopy measurements show that the electrochemically synthesized silver nanoparticles are deposited in aggregated form. The detection limit for this analytical procedure was 3.72 x 10(-7) M. In terms of reproducibility, the precision of the above mentioned method in %R.S.D. values was calculated at 2.58%. The method was applied satisfactorily to the determination of LTG in pharmaceutical preparations. (c) 2007 Published by Elsevier B.V.