Journal
DEVELOPMENT
Volume 134, Issue 22, Pages 4073-4081Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.006858
Keywords
extension; prechordal plate; axial mesendoderm; e-cadherin; epithelial-mesenchymal transition; cell adhesion; cell migration; DDC model
Categories
Funding
- MRC [G117/506] Funding Source: UKRI
- Medical Research Council [G117/506] Funding Source: researchfish
- Medical Research Council [G117/506] Funding Source: Medline
Ask authors/readers for more resources
The Snail genes are implicated in processes that involve cell movement, both during embryonic development and tumour progression. In teleosts, the vertebrate Snail1 gene is represented by two distinct genes, snail1a and snail1b ( previously snail1 and snail2). These genes are expressed in complementary mesodermal domains and their combined expression matches that of their mammalian counterpart. By analysing their loss and gain of function, we found that the most-anterior axial mesendodermal cells, the precursors of the polster, move in a cohesive manner directed by the activity of snail1a- and snail1b-expressing cells surrounding these precursors. The cell-autonomous function of Snail1 proteins regulates cell motility and influences the behaviour of Snail-negative neighbouring cells. Snail1a is required by the prechordal plate for it to reach its normal position, whereas Snail1b controls the acquisition of its normal shape. These non-redundant functions of Snail1a and Snail1b in controlling axial mesendoderm migration comply with the duplication-degeneration-complementation model, and indicate that Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available