Journal
VETERINARY MICROBIOLOGY
Volume 125, Issue 1-2, Pages 120-127Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2007.05.013
Keywords
Actinobacillus pleuropneumoniae; RTX toxin; live attenuated vaccine
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Previously, we reported the construction and characterization of a genetically defined Actinobacillus pleuropneumoniae (A. pleuropneumoniae) apxIIC gene mutant, 141304C(-), which conferred protection to mice against infection with A. pleuropneumoniae. In this study, we further evaluated HB04C(-) for safety and its ability to elicit protective immunity in pigs. It was demonstrated that a dose of 2 x 108 CFU HB04C(-) was safe to the pigs via intranasal or intramuscular injection. Immunization with a dose of 2 x 108 HB04C- by both intranasal and intramuscular routine could yield equal protective efficacy and elicited significant protection against experiment challenge with homologous or heterologous serotypes of a virulent A. pleuropneumonia. Taken together, HB04C- might serve as a promising vaccine candidate against infection with A. pleuropnetanoniae. (C) 2007 Elsevier B.V. All rights reserved.
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