Rynaxypyr™:: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

Rynaxypyr (TM) is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. (C) 2007 Elsevier Ltd. All rights reserved.