Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 23, Pages 5557-5560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm7009777
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Funding
- Intramural NIH HHS Funding Source: Medline
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Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but caused rapid apoptosis. Unlike the parent compound, 7b is toxic to both p53 positive and negative cancer cells. It. has potent in vivo activity against xenografts of human colon and pancreatic tumors in athymic mice.
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