☆ 4.5 Article

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

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Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 22, Pages 6206-6211

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.09.023

Keywords

GABA(B) positive allosteric modulators; GS39783; drug addiction

Categories

Chemistry, Medicinal Chemistry, Organic

Funding

  1. NIMH NIH HHS [U01 MH069062-02, U01 MH 69062, U01 MH069062-01, U01 MH069062-05, U01 MH069062-04, U01 MH069062-010002, U01 MH069062-03, U01 MH069062] Funding Source: Medline

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The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented. (C) 2007 Elsevier Ltd. All rights reserved.

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