Journal
BLOOD
Volume 110, Issue 10, Pages 3624-3626Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2007-05-093419
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Funding
- Medical Research Council [G0000111] Funding Source: researchfish
- MRC [G0000111] Funding Source: UKRI
- Medical Research Council [G0000111] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIPvariability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.
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