Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 363, Issue 2, Pages 405-410Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.08.186
Keywords
Bex1; Bex1-KO mice; calmodulin; CaM-binding protein; muscle regeneration; Omnibank; calcium; myogenesis
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Funding
- NIAMS NIH HHS [K01 AR053235, K01AR053235] Funding Source: Medline
- NIDCD NIH HHS [R01 DC003112, R01 DC003112-10] Funding Source: Medline
- PHS HHS [R01-03112] Funding Source: Medline
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Bex1 and Calmodulin (CaM) are upregulated during skeletal muscle regeneration. We confirm this finding and demonstrate the novel finding that they interact in a calcium-dependent manner. To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. These mice appeared to develop normally and are fertile, but displayed a functional deficit in exercise performance compared to wild type (WT) mice. After intramuscular injection of cardiotoxin, which causes extensive and reproducible myotrauma followed by recovery, regenerating muscles of Bex1-KO mice exhibited elevated and prolonged cell proliferation, as well as delayed cell differentiation, compared to WT mice. Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca2+/CaM may be involved in skeletal muscle regeneration. (C) 2007 Elsevier Inc. All rights reserved.
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