Journal
CANCER LETTERS
Volume 257, Issue 2, Pages 199-205Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.07.018
Keywords
RASSF1A; esophageal cancer; nasopharyngeal carcinoma; tissue microarray
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
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Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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