Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 363, Issue 3, Pages 727-732Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.09.033
Keywords
non-canonical Wnt; target genes; tropomodulin; gelsolin; promoter analysis; Tet-on inducible system; microarray analysis
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Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Writ signaling. We found that Tmod 1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a. As expected from the roles of genes regulated by Wnt5a, L929 cells expressing Wnt5a show abnormal cell shape and a reduced migration rate. Cloning and analysis of the putative promoter show that two conserved sequences, one in the 5'-end of the first exon and the other in the intron next to the first exon, are necessary for the basal promoter activity. (C) 2007 Elsevier Inc. All rights reserved.
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