Journal
VIROLOGY
Volume 368, Issue 2, Pages 317-321Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.07.015
Keywords
SARS; coronavirus; CD4(+) T-cell; immunity
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Funding
- NIAID NIH HHS [U19 AI057319, U19 AI57319, R21 AI060791-02, R21 AI060791-01, R21 AI060791] Funding Source: Medline
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Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses. (c)(c) 2007 Elsevier Inc. All rights reserved.
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