Journal
AQUACULTURE
Volume 272, Issue 1-4, Pages 180-187Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquaculture.2007.08.049
Keywords
Scylla serrata; enrofloxacin; metabolite; ciprofloxacin; salinity; pharmacokinetics
Categories
Ask authors/readers for more resources
The pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in the mud crab (Scylla serrata) kept at two salinities of 4 ppt and 33 ppt after a single oral gavage of 30 mg enrofloxacin per kg body weight. The concentrations of enrofloxacin and ciprofloxacin in the main tissues (hemolymph, muscle and hepatopancreas) were simultaneously detected by HPLC. The parameters in hemolymph and tissues were calculated by non-compartment model based on statistic moment theory. Area under the concentration-time curve from 0 to infinity h (AUC(0-infinity)), apparent volume of distribution (Vz), half-life (t(1/2)z)), body clearance (CLz) and mean residue time from 0 to infinity h (MRT(0-infinity)) in hemolymph were 1628.6 mu gh/ml, 1.73 L/kg, 65.09 h, 0.018 U h/kg and 83.72 h, respectively, at 4 ppt, and 3251.4 mu gh/ml, 1.547 L/kg, 116.22 h, 0.009 L/h/kg and 160.66 h, respectively, at 33 ppt. Peak levels of enrofloxacin in hepatopancreas were much higher than those in the hemolymph and muscle, at both salinities. Comparative pharmacokinetics in hemolymph, muscle and hepatopancreas showed slower elimination of enrofloxacin at 33 ppt than at 4 ppt. The AUC ratios of ciprofloxacin and enrofloxacin in mud crab hemolymph at 4 ppt and 33 ppt were only 4.0% and 3.8%, respectively. Mean residue time (MRT) and body clearance (CLz), deriving from statistical moment theory, indicated that ciprofloxacin eliminated slower at 33 ppt than at 4 ppt, the same as enrofloxacin. (c) 2007 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available