Journal
FEBS LETTERS
Volume 581, Issue 28, Pages 5440-5444Publisher
WILEY
DOI: 10.1016/j.febslet.2007.10.046
Keywords
breast cancer; chemotherapy resistance; tumor development; tumor suppressor; apoptosis
Funding
- NCI NIH HHS [R01 CA076406, CA 76406, R01 CA101992, CA 112102, CA 101992, R01 CA076406-05S1, R01 CA112102] Funding Source: Medline
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Expression of p53-target gene EI24/PIG8 is lost in invasive breast cancers, suggesting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeutic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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