Journal
FEBS LETTERS
Volume 581, Issue 28, Pages 5445-5453Publisher
WILEY
DOI: 10.1016/j.febslet.2007.10.047
Keywords
inorganic pyrophosphatase; PYP-1; deletion mutant; larval arrest; C. elegans
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Inorganic pyrophosphatase ( PPase) catalyzes the hydrolysis of inorganic pyrophosphate (PPi) into phosphate ( Pi), which provides a thermodynamic driving force for important biosynthetic reactions. The nematode Caenorhabditis elegans gene C47E12.4 encodes a PPase (PYP-1) which shows 54% amino acid identity with human PPase. PYP-1 exhibits specific enzyme activity and is mainly expressed in the intestinal and nervous system. A null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function. The larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene, suggesting that PYP-1 is required for larval development and intestinal function in C. elegans. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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