Journal
SCIENCE
Volume 318, Issue 5855, Pages 1402-1407Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1142033
Keywords
-
Categories
Funding
- Wellcome Trust [073980] Funding Source: Medline
Ask authors/readers for more resources
The nucleus is the defining feature of eukaryotic cells. It is a highly dynamic, membrane-bound organelle that encloses chromatin and thereby partitions gene transcription from sites of protein translation in the cytoplasm. Major cellular events, including DNA replication, messenger RNA synthesis and processing, and ribosome subunit biogenesis, take place within the nucleus, resulting in a continuous flux of macromolecules into and out of the nucleus through dedicated nuclear pore complexes in the nuclear envelope. Here, we review the impact of new technologies, especially in areas of fluorescence microscopy and proteomics, which are providing major insights into dynamic processes affecting both structure and function within the nucleus.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available