Journal
CANCER TREATMENT REVIEWS
Volume 33, Issue 8, Pages 704-709Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2007.08.006
Keywords
ALT; telomere; cancer; senescence; crisis; recombination; tumor
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Telomere shortening in the course of cell divisions plays an important rote in both suppression and pathogenesis of cancer. Telomere maintenance mechanisms such as telomerase and alternative lengthening of telomeres (ALT) are essential for long-term tumor growth. Consequently, interdiction of telomere lengthening has been proposed as an anti-cancer treatment but requires insight in the genes and pathways involved. In this article, the molecular and functional details of ALT are reviewed, and proposed next steps towards a therapy aimed at preventing ALT in human cancers are described. (c) 2007 Elsevier Ltd. All rights reserved.
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