Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 6, Pages 697-704Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.10.004
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Funding
- NCI NIH HHS [U54 CA132381, U54 CA132383] Funding Source: Medline
- NIGMS NIH HHS [R01 GM070887, R01 GM070887-03, GM070887] Funding Source: Medline
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Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing. recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.
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