Journal
NATURE REVIEWS GENETICS
Volume 8, Issue 12, Pages 932-942Publisher
NATURE RESEARCH
DOI: 10.1038/nrg2226
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Funding
- NCRR NIH HHS [R01 RR020833] Funding Source: Medline
- NICHD NIH HHS [P01 HD22486] Funding Source: Medline
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Reciprocal questions often frame studies of the evolution of developmental mechanisms. How can species share similar developmental genetic toolkits but still generate diverse life forms? Conversely, how can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways. First, it informs us about historical relationships, thus orienting the direction of evolutionary diversification. Second, genomics lists all toolkit components, thereby revealing contraction and expansion of the genome and suggesting mechanisms for evolution of both developmental functions and genome architecture. Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development.
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