Journal
QSAR & COMBINATORIAL SCIENCE
Volume 26, Issue 11-12, Pages 1274-1279Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/qsar.200740131
Keywords
azides; alkynes; click chemistry; catalysis; cycloaddition
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Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
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