Journal
BIOMATERIALS
Volume 28, Issue 34, Pages 5093-5099Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.07.030
Keywords
scaffold; polymer; tissue engineering; tissue analogue; molecular signals
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In designing scaffolds for tissue regeneration, the principal objective is to recapitulate extracellular matrix (ECM) function in a temporally coordinated and spatially organised structure. A key issue is to encode required biological signals within the scaffold so that all aspects of cell response-adhesion and migration, proliferation and phenotype choice-can be controlled. In achieving this objective nanotechnology, bottom-up design approach and solid free-form fabrication (SFF) will play key roles, along with self-assembly processes. For scaffold materials, there must be the correct balance between architectural features notably, porosity and chemical, physical and biological properties. This paper reviews the main achievements in biomaterials design and the future challenges. (C) 2007 Elsevier Ltd. All rights reserved.
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