Journal
NANO LETTERS
Volume 7, Issue 12, Pages 3759-3765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl072209h
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- NIDDK NIH HHS [1 T90 DK070121-01] Funding Source: Medline
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Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as Trojan Horses for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
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