Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 18, Issue 6, Pages 489-496Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2007.09.003
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D006104/1] Funding Source: researchfish
- BBSRC [BB/D006104/1] Funding Source: UKRI
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Fragment-based approaches have provided a new paradigm for small-molecule drug discovery. The methodology is complementary to high-throughput screening approaches, starting from fragments of low molecular complexity and high ligand efficiency, and building up to more potent inhibitors. The approach, which depends heavily on a number of biophysical techniques, is now being taken up by more groups in both industry and academia. This article describes key aspects of the process and highlights recent developments and applications.
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