Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 91, Issue 5, Pages 887-894Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.14-0333
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Funding
- Fondos del Sistema-Consejo Nacional de Rectores (FEES-CONARE), Vicerrectoria de Investigacion, University of Costa Rica [741-B2-652, 741-B3-017]
- Australian National Health and Medical Research Council (Australia)
- Papua New Guinea Office of Higher Education
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Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of the taipan snakes (Oxyuranus scutellatus) from Australia and Papua New Guinea (PNG), respectively, were compared using antivenomics, an analytical approach that combines proteomics with immunoaffinity chromatography. Both antivenoms recognized all venom proteins present in venom from PNG O. scutellatus, although a pattern of partial recognition was observed for some components. In the case of the Autralian O. scutellatus venom, both antivenoms immunorecognized the majority of the components, but the CSL antivenom showed a stronger pattern of immunoreactivity, which was revealed by the percentage of retained proteins in the immunoaffinity column. Antivenoms interacted with taipoxin in surface plasmon resonance. These observations on antivenomics agree with previous neutralization studies.
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