Journal
TRENDS IN CELL BIOLOGY
Volume 17, Issue 12, Pages 571-574Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.10.001
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The molecular mechanisms required for sensing high osmolarity in the extracellular environment are not well defined in eukaryotes. A recent study showed that yeast Msb2 and Hkr1, which are related to mammalian mucins, are excellent candidates for sensing osmostress and for activating the HOG stress-activated protein kinase pathway involved in osmostress adaptation. Transmembrane mucins activate several signaling cascades in mammals and could therefore be important for sensing osmotic imbalances in higher eukaryotes.
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