Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 6, Issue 4, Pages 275-281Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2007.908981
Keywords
carbohydrates; cell response; endocytosis; magnetic nanoparticles; nanoparticles
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Magnetic nanoparticles have been used in therapeutic and diagnostic approaches in biomedicine for many years. For these applications, it is very important to investigate the nanoparticle-cell interactions. In this study we report a simple method for the preparation of gold-iron nanoparticles protected and functionalized with biologically relevant saccharides (maltose, lactose, and glucose). The nanoparticles were subsequently tested in vitro with a human fibroblast cell line to determine biocompatibility, and the cell-particle interactions, using fluorescence and scanning electron microscopies. Different cellular responses were obtained for each type of glyconanoparticle, demonstrating that the cells can recognize the saccharides on the nanoparticles.
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