Journal
SURGICAL ONCOLOGY-OXFORD
Volume 16, Issue -, Pages S37-S42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.suronc.2007.10.018
Keywords
colorectal cancer; genes; microsatellite instability
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Microsatellite instability (MSI) is observed in approximately 13% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumourigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumours. MSI caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary non-polyposis colorectal cancer syndrome but is also found in about 15% of all sporadic tumours. (c) 2007 Elsevier Ltd. All rights reserved.
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