Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 89, Issue 1, Pages 188-194Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.12-0774
Keywords
-
Funding
- National Health and Medical Research Council (NHMRC) of Australia [1003825, 1010203]
- Bill and Melinda Gates Foundation
- NHMRC
Ask authors/readers for more resources
Despite having the highest Plasmodium vivax burden in the world, molecular epidemiological data from Papua New Guinea (PNG) for this parasite remain limited. To investigate the molecular epidemiology of P. vivax in PNG, 574 isolates collected from four catchment sites in East Sepik (N = 1) and Madang (N = 3) Provinces were genotyped using the markers MS16 and msp1F3. Genetic diversity and prevalence of P. vivax was determined for all sites. Despite a P. vivax infection prevalence in the East Sepik (15%) catchments less than one-half the prevalence of the Madang catchments (27-35%), genetic diversity was similarly high in all populations (H-e = 0.77-0.98). High genetic diversity, despite a marked difference in infection prevalence, suggests a large reservoir of diversity in P. vivax populations of PNG. Significant reductions in transmission intensity may, therefore, be required to reduce the diversity of parasite populations in highly endemic countries such as PNG.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available