Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 192, Issue 1-2, Pages 219-225Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.10.002
Keywords
sHLA-G1; HLA-G5; cerebrospinal fluid; Multiple Sclerosis
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Cerebrospinal fluid (CSF) levels of sHLA-G (sHLA-G1/HLA-G5) molecules and their soluble isoforms HLA-G5 and sHLA-G1 were measured by ELISA procedures in 68 relapsing-remitting Multiple Sclerosis (RR MS) patients, in 67 patients with other inflammatory neurological disorders (OIND) and in 70 subjects with non-inflammatory neurological disorders (NIND). CSF concentrations of sHLA-G1/HLA-G5 and HLA-G5 were higher in RR MS than in OIND and NIND, and in Magnetic Resonance Imaging (MRI) inactive as compared to MRI active RR MS. Our results indicate that the potential implication of sHLA-G proteins in the resolution of MS intrathecal inflammatory response is probably due to HLA-G5 isoform. (C) 2007 Elsevier B.V. All rights reserved.
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